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Figure 2


Fig. 2. Histology reveals normal fiber morphology in the lens of {alpha}3(-/-) {alpha}8(G22R/KI{alpha}3) mice. (A) The {alpha}3(-/-) {alpha}8(G22R/-) lens of a 2-week-old mouse has severely degenerated inner fibers and posterior rupture of the lens capsule. (B) The {alpha}3(-/-) {alpha}8(G22R/KI{alpha}3) lens section of a 2-week-old mouse shows relatively normal inner lens fibers without any obvious cell degeneration. The defect in the center fibers could either be caused by sectioning artifacts or the mild nuclear cataract.