JCS -- Rooney et al. 119 (11): 2185 Figure IG6

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Fig. 6. Increased expression of eMyHC in mdx/ ${alpha}$ 7^-/- mice. (A) Immunofluorescence was used to detect eMyHC expression in tibialis anterior muscle fibers from 3-week-old mice. Muscle from wild-type, mdx and ${alpha}$ 7^-/- mice showed few eMyHC-positive fibers (green). Many muscle fibers from mdx/ ${alpha}$ 7^-/- mice were positive for eMyHC. Rhodamine-labeled WGA (red) was used to define muscle fibers. Bar, 10 µm. (B) Quantitation of eMyHC-positive fibers. Few eMyHC-positive muscle fibers were counted in wild-type, mdx or ${alpha}$ 7^-/- mice. By contrast, an average of 7.46 fibers per field were positive for eMyHC in mdx/ ${alpha}$ 7^-/- mice, which is significantly different from the controls (^*P<0.05).