Fig. 1. Urine and serum osmolality. (A) Urine osmolality was measured at multiple time points. Data are shown as the mean ± s.e.m. of 4-10 mice per time point. ^**P<0.001 compared with +/+ mice (ANOVA). (B) Serum osmolality was measured 18-24 days post-natal. Bars show the mean ± s.e.m. of 4-6 mice. ^*P<0.05 compared with +/+ mice (Student's t-test). (C) Urine osmolalities of +/+, +/-, and -/- mice were measured before and 60 minutes after DDAVP application. Data shown are ten mice per genotype. ^*P<0.05 compared with +/+ mice (Student's t-test), ^**P<0.05 (paired t-test).