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Figure 10


Fig. 10. Schematic representation of the chromatin-remodelling function exerted by PML-NBs on the juxtacentromeric satellite DNA. Chromatin-remodelling proteins and satellite DNA transiently colocalise within the PML-NBs during G2 phase. The mean percentages of colocalisation, obtained from the analysis of 100 cells of three control subjects (C1, C2, C3) at the S, G2 and M phases are respectively 8.5%, 24.6%, 6.1% for 1qh, and 8.3%, 25.4%, 5.8% for 9qh. These results support a chromatin-remodelling function of PML-NBs specific to the G2 phase (sat DNA, satellite DNA; cen, centromeric DNA).