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Figure 2


Fig. 2. Neither acute elevation of cAMP nor inhibiting Rho kinase activity is sufficient to overcome the inhibitory effect of aggrecan on axon assembly from adult DRG neurons. (A) Neither addition of dbcAMP (1 mM) nor addition of Y27632 (25 µM) induced axon growth from naive neurons cultured on aggrecan and laminin in the presence of NGF. (B) Addition of the Rho kinase inhibitor Y27632 had little effect on axon assembly from the PCL neurons cultured on aggrecan and laminin. *P<0.01 and #P<0.05 compared with levels in the control group.