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Figure 9


Fig. 9. A model illustrating how PDGF uses two distinct pools of SFKs for DNA synthesis and dorsal ruffle formation. PDGF activates SFKs in caveolae (grey) allowing phosphorylation of mitogenic substrates for Myc induction and DNA synthesis. PDGF recruits sphingosine kinase (SK1) to the membrane through a PLC{gamma}-dependent pathway for S1P formation. S1P further activates SFK outside caveolae through an EDG receptor coupled to a heterotrimeric Gi protein allowing Abl activation for dorsal ruffle formation. Additional Src substrates (others) may be expected for induction of this morphological change. S, sphingosine.