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Figure 3


Fig. 3. Dok-4 mediates sustained ERK and AKT activation in the GDNF/RET signaling pathway. TGW cells, TGW cells stably expressing Dok-4 [TGW(Dok-4)], or Dok-4 knockdown cells [TGW(Dok-4 siRNA)] were serum-starved and stimulated with GDNF (50 ng/ml) for the indicated times, and cell extracts subjected to western blot analysis with the indicated antibodies.