Fig. 1. Comparison of erlin-1, erlin-2 and other PHB family members. (A) CLUSTALW alignment of erlin-1 and -2. Non-conserved, similar, conserved and identical (all match) amino acid residues are indicated by shading as described in the legend. (B) Schematic alignment of erlin-1 and -2 with other PHB family members. PHB domains are represented by grey-filled regions and demarcated by bordering amino acid numbers. Putative transmembrane domains are indicated by light-grey regions outside of the PHB domains and dark grey regions within the PHB domains. The overlap between the two PHB domains of flotillin-1 is represented by the black filled region. The palmitoylation sites of stomatin-1a and flotillin-1 are demarcated by asterisks (^*). (C) PHYLIP rooted dendrogram of PHB family members.