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Figure 4


Fig. 4. Cellular response of crest cells to LN-5. (A) Diagram showing the schematic structure of LN-1, LN-5 and LN-10/11. The {alpha}3 subunit of LN-5 in its mature form is much shorter than its {alpha}1 counterpart in LN-1, and only one integrin-binding site situated towards its C-terminal part has been mapped. Likewise, although the {alpha}5 subunit of LN-10/11 resembles the {alpha}1 chain except for its length, it apparently does not contain integrin-binding domains in its N-terminus. (B-D,G) Adhesion, spreading, motility and survival on LN-1, LN-5 and LN-10/11 at 1, 10 and 50 µg/ml. (E,F) Morphology and migration on LN-5 at 50 µg/ml and LN-10/11 at 20 µg/ml. Bar, 100 µm; nt, neural tube.