Fig. 5. Jun siRNA inhibits angiogenesis in mice. C57BL/6 mice were implanted subcutaneously with Matrigel plugs containing 0.5 µg FGF-2 and 100 µg Jun siRNA or Jun siRNAscr or no siRNA. Blood vessels (CD31⁺, top panel inset) in the cross-sectioned plugs were quantified by light microscopy 14 days after implantation. The figure shows representative cross-sections of the treated plugs (magnification, 400x). ^*P<0.05 by Student's t-test between groups as indicated.