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Figure 10


Fig. 10. Simplified model to explain the mechanism of daughter centrosome separation and migration in the early cleavage (cycles 2-10) Drosophila embryos. The interpolar microtubules, nucleated by the daughter centrosomes (large arrowheads) exert pushing force and begin to separate the daughter centrosomes. Microtubules containing {alpha}4-tubulin bend around the nuclear envelope while they grow. Dyneins fixed to the nuclear envelope (not shown) keep the microtubules attached and use them as a migration route to pull the centrosomes in the indicated directions. Centrosome migration stops when the interpolar microtubules bend away from the nuclear envelope and the centrosomes organize symmetric array of microtubules equalizing inward and outward forces.