Fig. 1. Effect of CK2 inhibitors on HIF-1 and p53 protein level in HepG2 and HeLa cells. Cells were incubated for 5 hours under normoxia or hypoxia in the presence or the absence of different concentrations (µM) of DRB (A,C), apigenin (A,C) or of 10 µM TBB (B). Total cell lysates were tested for HIF-1, p53, phospho-Ser392 p53 and -tubulin by western blotting.