JCS -- Hubert et al. 119 (16): 3351 Figure IG12

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Fig. 12. Schematic representation of the possible role of CK2 in p53-dependent regulation of HIF-1 activity. Under hypoxia, elevated CK2 activity triggers p53 degradation, thus relieving p53 inhibition on HIF-1, leading to active HIF-1. When CK2 is inhibited, p53 is stabilized, competes with HIF-1 ${alpha}$ for p300, lowering HIF-1 activity.