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Figure 1


Fig. 1. Domain structure of AF6, afadin and canoe. (A) Domain structure of the three AF6 isoforms (AF6i1, AF6i2 and AF6i3), the two isoforms of its rat homologue afadin (long l-afadin and short s-afadin) and its Drosophila homologue canoe. Aa positions of individual AF6 domains are annotated. RA1,2: Ras-associating domain 1 and 2; FHA: forkhead associated domain; DIL: dilute domain; PDZ: PSD-95-Dlg-1-ZO-1 domain; pro: proline-rich domain. (B) Western blot analysis of HEK293 whole-cell lysate, using anti-AF6 antibody, showing the endogenous AF6i3 protein (left) and the endogenous plus the overexpressed AF6i1 protein (right).