Fig. 2. Schematic of +TIP function during nuclear orientation to the shmoo tip. (A) In unbudded cells, Kar9p (red) and Bik1p (purple) are transported along the MT (green) by the motor protein Kip2p (brown) to the plus end where Bim1p (blue) binds. Kar3p (cyan) and Cik1p (yellow) form heterodimers that localize near the plus ends. (B) After cell polarization, the MT plus end interacts with actin cables (red) via Myo2p (gray). Myo2p links to Bim1p through Kar9p and moves the nucleus towards the shmoo tip. (C) Once at the shmoo tip, the plus end interacts persistently with the shmoo tip. This interaction could be mediated by proteins at the shmoo tip cortex that act as attachment factors.