Fig. 3. Liver atrophy and kidney outer medulla hypoplasia in the Sox17^+/--Sox18^-/- neonates at P7 and P14. (A-D) HE-staining of the affected Sox17^+/--Sox18^-/- livers at P7 (A,B) and P14 (C,D) showing atrophy of the hepatocytes (asterisks in A,B and whole area in C,D). cv, central vein; hc, hematopoietic cells. (E-H) HE-staining of the affected Sox17^+/--Sox18^-/- kidneys at P7 (E,F) and P14 (G,H), showing the hypoplasia of the outer medulla that might result in variable degrees of hydronephrosis. In the affected Sox17^+/--Sox18^-/- kidneys, their outer medulla showed dysmorphogenesis (E,G), in which the running patterns of vasa recta appeared to be irregular (arrowheads and arrows in F,H). ct, cortex; im, inner medulla; om, outer medulla; rp, renal papilla. The boxed area encompasses the area magnified in the designated panel. Bars, 50 µm (for A-D,F,H) and 100 µm (for E,G).