Fig. 5. Transmission electron micrographs showing ischemic necrosis of hepatocyte and renal tubular epithelia in the affected livers (A-C) and kidneys (D-F) of the P7 Sox17^+/--Sox18^-/-neonates. (A-C) Enlarged sinusoidal lumen and Disse's space in the affected Sox17^+/--Sox18^-/- livers (right in A-C). Their surrounding hepatocytes (hc) are smaller in size, and some of them displayed necrosis and vacuolation with swollen mitochondria and dilated rough endoplasmic reticulum (asterisks in A,B). Ds, Disse's space; ec, endothelial cell; hc, hepatocyte. (D-F) Normal vascular structures of vasa recta around renal tubular epithelia in the affected Sox17^+/--Sox18^-/- kidneys at P7 (D,E). However, some tubular epithelia display necrotic morphology (asterisk in F). ec, endothelial cell; te, renal tubular epithelial cells. Bars, 5 µm.