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Figure 2


Fig. 2. Hypoproliferative epidermis and skin barrier defects in the bi-transgenics. (a) Decreased proliferation in the epidermis of the K5tTA/TRE-Klf5 bi-transgenic embryos (E16.5) compared with the wild type. Haematoxylin-Eosin-stained sections of dorsal skin at E16.5 (upper panel). Immunohistochemical staining of E16.5 dorsal skin with the anti-Ki67 antibody (lower panel). Bar, 50 µm. (b) Defective skin barrier in a bi-transgenic embryo compared with a wild-type embryo at E17.5.