JCS -- Girdler et al. 119 (17): 3664 Figure IG5

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Fig. 5. ZM2 and ZM3: novel Aurora kinase inhibitors. (A) Chemical structures of ZM1, ZM2 and ZM3. Note that ZM1 is ZM447439 as described (Ditchfield et al., 2003). (B) Table summarising results from in vitro kinase assays to determine the effects of ZM compounds on Aurora kinase activity. Shown are the IC₅₀ values; the relative potency of ZM2 and 3 with respect to ZM1; and the selectivity of each ZM compound towards Aurora B relative to Aurora A.