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Figure 1


Fig. 1. MT dynamic instability. (Left to right) GTP-tubulin (dark green) adopts a straight conformation that favours MT polymerisation. MT polymers are polar with ß-tubulin at the plus end and {alpha}-tubulin at the minus end. Dynamic instability occurs at both ends but only the plus end is illustrated for clarity. GTP is hydrolysed within the MT lattice to GDP (light green) but GDP-tubulin is held in place by the lattice until hydrolysis occurs at the MT end, catastrophe occurs and MTs depolymerise.