Fig. 1. Homology of erasin proteins found in different species. (A) Sequence alignment of erasin proteins in selective eukaryotic organisms. Homologous amino acids in four or more sequences, including gaps, are shaded. The UBX domain is underlined. The dashed line is the sequence that covers the region that was necessary and sufficient for ER targeting. (B) Reconstructed phylogenetic tree of the erasin homologs using the AssemblyLIGN software.