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Figure 5


Fig. 5. PI3K affects actin reorganization. FITC-coupled phalloidin detected polymerized F-actin filaments (green) in 4-OHT- or solvent-treated Myr-p110{alpha}*-mER cell clones (clone #17, A,C,E,F) or vector-transfected control clones (B,D). Arrowheads indicate cells with accumulated actin filaments at the cell periphery (C,F). Distribution of paxillin is depicted in red (E,F). Nuclei were counterstained with Hoechst 33342 (blue). Bars, 50 µm.