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Figure 1


Fig. 1. PRL-based array construction and testing. (A) Sequence of the prolactin promoter (+1 to -66) with one high-affinity Pit-1-binding site (1P, italics and underlined) and enhancer (-1807 to -1498) that contains four Pit-1-binding sites (1D-4D, italics and underlined), and five EREs (PRL1-5, Bold text). (B) Sequence of the synergy element containing the Pit-1 1D site and two EREs (PRL1 and 5). (C) Schema showing the essential elements of the reporter constructions. Transcription start site, proximal promoter and enhancer sequence are shown in A. Xn indicates multimerized synergy elements denoting variable numbers of repeats (8, 13, 26, 52, 104).