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Fig. 1. Dystroglycan domain organization. In the mature {alpha}-dystroglycan ({alpha}-DG), the N-terminal domain is cleaved by convertase-like activity between Arg312 and Gln313. Circles indicate O-linked sugar chains. Branches indicate N-linked sugar chains. SP, signal peptide; TM, transmembrane domain; PPXY, dystrophin-binding site. Molecular masses at the bottom refer to the protein mass in the absence (core) and presence of post-translational glycosylation.