Fig. 5. Sequence alignments of five known grip-motif-containing Drosophila TuRC subunits (Dgrip75, Dgrip84, Dgrip91, Dgrip128 and Dgrip163) with Dgrip79, a protein identified in database searches on the basis of the presence of the grip motifs; it is not yet known whether Dgrip79 is a component of the TuRC. (A) An overall sequence alignment shows two regions of higher sequence similarity (orange), labeled `grip motif 1' and `grip motif 2', shared among the six grip-domain proteins. (Please note that the sequence of Dgrip163 was truncated except in regions of homology to the other grip proteins.) The number of amino acids for each of the proteins is indicated to the right of the alignments. (B,C) Sequence alignments of (B) grip motif 1 or (C) grip motif 2. Starting and ending amino acid numbers, respectively, are listed at the left and the right of the alignment for each protein. Shading indicates the degree of sequence conservation (see key). Sequence alignments were generated using the `T-coffee' algorithm (Notredame et al., 2000; Poirot et al., 2004).