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Figure 2


Fig. 2. Low bone mass phenotype in conditionally Cx43 deleted mice. (A) Whole mount of alizarin red and alcian blue staining of newborn mice did not reveal any major skeletal abnormalities in ColCre;Cx43–/fl mice compared with their control littermates. (B) Lower body weight in ColCre;Cx43–/fl (n=46) relative to Cx43+/fl (n=69) and Cx43–/fl groups (n=42) at 6 months of age. (C) Whole-body BMD measured by DEXA monitored in vivo revealed significantly lower bone mass in ColCre;Cx43–/fl relative to wild-type littermates (P<0.05, for genotype effect; two-way ANOVA for repeated measures).