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Figure 5


Fig. 5. Attenuated BMC response to PTH in osteoblast Cx43-deficient mice. Percent change from baseline of whole body BMC after a 4-week treatment with different doses of teriparatide (PTH), showing a dose-related increase of bone mass in wild-type Cx43+/fl mice (A). Effects of lesser magnitude were observed in heterozygous equivalent Cx43–/fl mice at the intermediate doses (B), whereas the effect of PTH treatment was uniformly attenuated at all doses in ColCre;Cx43–/fl mice (C). *P<0.05, **P<0.01 versus vehicle (one-way ANOVA); n=6-8 per each data point. Data are mean ± s.e.m.; n=12 (vehicle) and 6-8 (PTH-treated groups).