Fig. 6. Spatial organization of PML bodies in caspase-8 activated hMSCs. Human MSCs at passage four were transduced with CenpA-GFP (A) or lamin B-GFP (B), and with FKC8 lentiviral vectors. FKC8 was activated with 100 nM AP20187 for 6 hours (+AP20187). Mock-treated cells were left without AP20187 treatment. Subsequently, cells were subjected to immunostaining using an anti-hPML antibody. Confocal images were processed with TeloView. CenpA-GFP and lamin B-GFP are shown in green and PML is shown in red. Bars, 5 µm.