JCS -- Fassio et al. 119 (20): 4257 Figure IG7

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Fig. 7. L7-pepE PC terminals exhibit milder depression and faster recovery after prolonged high-frequency stimulation. (A) Effect of prolonged stimulation trains (50 Hz for 2 minutes) on IPSC amplitude. A representative experiment shows the faster and more intense synaptic depression in wild-type mice (left) with respect to Tg-2 mice (right). (B) Left panel, IPSC amplitudes during the prolonged stimulation are expressed in percent of the first IPSC. The IPSC decrease was smaller in L7-pepE ( $bullet$ , n=4) than in wild-type ( ${circ}$ , n=5) mice. Statistical analysis was performed on the steady-state levels (50-120 seconds) using the Student's unpaired t test (P<10^–8). Right panel, the number of failures during prolonged stimulation trains was lower in L7-pepE ( $bullet$ , n=4) than in wild-type ( ${circ}$ , n=5) mice. Data are reported as means ± s.e.m. Statistical analysis was performed on the steady-state levels (50-120 seconds) using the Student's unpaired t test (P<10^–13).