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Figure 2


Fig. 2. cPAR3 colocalizes with cNumb at intercellular junctions. cNumb accumulates at the apical membrane (arrowhead in A) and at cytoplasmic vesicles (arrowheads in B). (C-C'') cPAR3 colocalizes with cNumb at the apical membrane of NEP cells. (D) cPAR3 is co-immunoprecipitated with cNumb in NEP protein lysates. CRMP2 is used as control. Conversely, cNumb co-immunoprecipitates with cPAR3 (E). (F) cNumb accumulates at the apical membrane together with ß-Catenin and N-Cadherin (G). L, lumen of the NT. Magnification in (A), 20x. Bar in (B), 6 µm; bars in (C-C''), 3 µm; bars in (F,G), 2 µm.