Fig. 6. Ectopic expression of lamin A induces formation of the pore-free islands. Transient expression of Venus-lamin-A in HeLa cells with uniform pore distributions. Nuclear surface images of HeLa cells (Fig. 4A) expressing Venus-lamin-A and stained for nuclear pores. Enrichment of expressed Venus-lamin-A induces distinct pore-free islands (arrows).