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Figure 2


Fig. 2. Multiple cellular pools of {alpha}-catenin. {alpha}-Catenin exists in multiple cellular pools: incorporated into the cadherin complex at the plasma membrane; as monomers, homo- and hetero-dimers in the cytosol; and potentially also in the nucleus. Both in the cytosol and in the nucleus, cadherin-independent {alpha}-catenin may regulate ß-catenin signalling in the canonical Wnt pathway by forming heterodimers with ß-catenin. {alpha}, {alpha}-catenin; ß, ß-catenin; Dsh, dishevelled; Pygo, Pygobus; TCF, T-cell factor.