JCS -- Candi et al. 119 (22): 4617 Figure IG5

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Fig. 5. Proposed mechanism of action of p63 upstream of IKK ${alpha}$ . TAp63 ${alpha}$ and ${Delta}$ Np63 ${alpha}$ have different, synergistic functions in the formation of the epidermis; TAp63 exerts its effects, at least in part, by acting directly upstream of IKK ${alpha}$ (which is also indirectly transactivated via Ets-1 and GATA-3), whereas ${Delta}$ Np63 can only activate IKK ${alpha}$ indirectly, at least partly via GATA-3. bm, basal membrane; bl, basal layer of keratinocytes; CE, cornified envelope.