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Figure 1


Fig. 1. Structure of CCN family members. The CCN family members, CCN1 (Cyr61), CCN2 (CTGF), CCN3 (nov), CCN4 (WISP-1), CCN5 (WISP-2) and CCN6 (WISP-3) have a shared structure, consisting of a secretory signal peptide (SP), an IGF-binding domain (Module I), a von Willebrand type C domain (VWC, Module II), a thrombospondin-1 domain (TSP-1, Module III) and a cysteine knot (Module IV) domain. Domains are linked by hinge regions, susceptible to protease cleavage.