Fig. 10. Binding sites for various IF proteins on the tail of DP. The linker region between the B and C plakin-repeats and the C-terminal extremity contain sequences critical for IF binding and ensure binding specificity. The B and C plakin-repeat domains participate in the association by providing additional binding sites and/or affecting the proper folding of the linker region and C-terminal extremity. While the linker region and the B plakin repeat of DP contain the minimal sequences required for its association with desmin, the C plakin repeat and C-terminal extremity contribute to efficient binding.