Fig. 9. Granulation tissue contraction. (A,B) H and E staining of 14-days-old wound granulation tissue in wounds treated with control sODN (A) and asODN (B). (C) Area of granulation tissue after treatment with control sODN (white bars) or Cx43-asODN (black bars) analyzed on day 5 (control, n=7; asODN, n=6), day 7 (control, n=5; asODN, n=5), day 10 (control, n=5; asODN, n=6), and day 14 (control, n=5; asODN, n=6). Granulation tissue area measurements at day 5 already showed a slightly smaller area after treatment but the reduction became significant on days 7, 10 and 14 (^*P<0.05, ^**P<0.01). Data are expressed as the mean ± s.e.m. Bars, 1 mm.