JCS -- Naik and Naik 119 (3): 490 Figure IG4

(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.

Fig. 4. JAM-A-induced HUVEC migration on vitronectin is integrin ${alpha}$ _vß₃ specific. HUVECs stably transfected with JAM-A or mock transfected were pre-treated with various concentrations of antibodies or inhibitors as indicated. Cell migration assays on vitronectin or fibronectin were performed as described in the Materials and Methods. (A) Pre-treatment with anti- ${alpha}$ _vß₃ antibody (*P<0.05), (B) pre-treatment with anti- ${alpha}$ _vß₅ antibody, (C) pre-treatment with XT199 RGD-based antagonist specific to integrin, (D) same as in (C) on fibronectin.