JCS -- Matthews et al. 119 (3): 508 Figure IG7

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Fig. 7. Contributions of Rho, mechanosensitive ion channels and Src tyrosine kinases to the adaptive repositioning response to prolonged stress. RGD-beads bound for 10 minutes to cells were exposed to a prolonged (60 seconds in A,B; 30 seconds in C) stress (350 pN) applied in a centripetal direction opposite to that which beads normally move on the cell surface. (A) Bead displacements relative to the nucleus were measured in cells exposed to the BioPORTER proteofection reagent in the absence ( $bullet$ ) or presence ( ${square}$ ) of C3 transferase. (B) Bead displacements measured in the absence ( ${diamondsuit}$ ) or presence ( ${diamond}$ ) of gadolinium chloride. (C) Bead displacements measured in the absence ( ${blacksquare}$ ) or presence ( ${square}$ ) of PP2. Error bars indicate s.e.m.; P<0.05 at times greater than 30 seconds compared with controls in all graphs.