Fig. 9. Schematic drawings illustrating possible effects of EphB2 signaling in medullary kidney epithelial cells. On the basis of the effects of ephrin-B1–Fc treatment in cultured medullary tubule cells, we propose that, in the kidney, EphB2 might regulate the geometry of the basal infolds and the gaps between cells through membrane retraction and remodeling of cell-matrix adhesion sites.