Fig. 2. Regulation of endocytic membrane trafficking by PI 3-kinases. The figure gives an overview of membrane trafficking in the endocytic pathway. Effectors of PtdIns(3)P are indicated in blue. EE, early endosome; MVE/LE, multivesicular endosome/late endosome; MT, microtubule; RE, recycling endosome; TGN, trans-Golgi network. Arrow thickness corresponds to the magnitude of various trafficking pathways indicated.