Fig. 5. Loss of Par-1 causes a neurogenic phenotype in late stage embryos. Embryos stained for neuron-specific Neuroglian at stage 15; whole embryos (left panels) and representative segments of peripheral nerves (right panels). (A,B) Wild-type embryos develop highly organized central and peripheral nervous systems with characteristic numbers of neurons. (C,D) par-1(RNAi) embryos and (E,F) N^55e11 mutants display hyperplasia of central and peripheral nervous systems. (G,H) scrib(RNAi) embryos and (I,J) shg², (K,L) baz^XI106 and (M,N) crb^11A2 mutants all show defects in nervous system development, but have negligible to minor neural hyperplasia.