JCS -- Estrada et al. 119 (4): 733 Figure IG5

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Fig. 5. Effect of Ins(1,4,5)P₃R type 1 knock-down on testosterone-induced Ca²⁺ oscillations. (A,B) Cells transiently transfected with Ins(1,4,5)P₃R type 1 siRNA (InsP₃R1), showed a significant reduction ( $~$ 80%) of the immunosignal. (C) In Ins(1,4,5)P₃R type 1-siRNA transfected cells two types of Ca²⁺ response to testosterone were observed. The magnitude of the transient was reduced by 68% compared with untransfected cells, or abolished. (D) Control trace in cells not expressing the Ins(1,4,5)P₃R siRNA.