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Figure 1


Fig. 1. The effect of MAPK and PI3K inhibitors on MK proliferation. Proliferation of HPCs along the megakaryocytic lineage in the presence of 100 ng/ml TPO alone (Control), or in combination with 10 µM PD98059 or 10 µM U0126 or 10 µM LY294002 or 50 nM rapamycin. All the inhibitors were dissolved in DMSO, and an equivalent volume of DMSO was added to the control cultures. Data are expressed as the mean ± s.e.m. of six separate experiments.