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Figure 1


Fig. 1. The Varp protein sequence. (A) Alignment of human Rabex5 and Varp N-terminal fragment. The solid line indicates the VPS9 domain. (B) Alignment of a part of the VPS9 domains from human Rabex5 (hRabex5), human RIN1 (hRIN1), human ALS2 (hALS2), S. cerevisiae Vps9p (scVps9), human Varp (hVarp) and mouse Varp (mVarp) protein sequences. The shaded regions (black and gray) represent identical and conserved amino acids, respectively. Arrowheads indicate the four crucial amino acids in Rabex5 required for the GEF activity.