Fig. 5. (A) Alignment of the sequence conserved between myopalladin and palladin that mediates binding of the SH3 domain of nebulin. The poly-proline motif responsible for the nebulin and Lasp-1 interactions is indicated by an asterisk. (B) Alignment of the SH3 domain of nebulin with the SH3 domain of Lasp-1. The core SH3-domain sequence is 80% identical.