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Figure 2


Fig. 2. Summary of GIT1 protein interactions and functions. Major signaling pathways include (A) agonist (Ag)-receptor (GPCR) endocytosis; (B) angiotensin-II (AngII)-stimulated PLC{gamma} activation and Ca2+ mobilization; (C) scaffolding MEK1 activation in response to TRK activation; (D) cytoskeletal regulation through PAK and Rho-family GTPases; and (E) focal complex assembly and disassembly. G, heterotrimeric G proteins; GRK, GPCR kinase; GPCR, G-protein-coupled receptor; IP3, inositol (1,4,5)-trisphosphate; P, phosphorylation; TKR, tyrosine kinase receptor.