JCS -- Hoefen and Berk 119 (8): 1469 Figure IG3

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Fig. 3. Rac1/Cdc42-stimulated PAK activation requires GIT-PIX oligomers. Activated Rac1 and Cdc42 interact with inactive PAK, causing a conformational change that allows it to bind to GIT-PIX oligomers through a direct interaction with PIX. High local concentrations of PAK permit autophosphorylation (P), stimulating the kinase activity of PAK and its subsequent disassociation from the GIT-PIX oligomers.