Fig. 5. Quantitative assessment of histopathology in tibialis anterior muscles of 12-week-old mice. (A) Percentage of fibers with central nuclei. (B) Box plots show variance in the muscle fiber diameter. Boxes represent the middle quartiles from the 25th to 75th percentiles, bars represent high and low values (statistical outliers are shown as circles). Each data set is composed of >1000 fibers of n=3-6 mice each. ANOVA statistical tests were performed on measurements of % central nuclei and the median fiber diameters. *P<0.01, statistical difference compared with C57Bl/6; ^#P<0.01, statistical difference compared with mdx^4cv; P<0.05, statistical difference compared with C57Bl/6.