JCS -- Gondré-Lewis et al. 119 (9): 1876 Figure IG5

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Fig. 5. Fate of proteins within the regulated secretory pathway in SLOS mice. (A) In vivo expression of ${alpha}$ -amylase was analyzed by western blot of protein from whole pancreas of newborn SLOS littermates. (B) Quantification of bands shows abundant presence of ${alpha}$ -amylase in both WT and SLOS mutants, with SLOS tissues exhibiting a 15% decrease in accumulation at steady state. (C) Plasma levels of ${alpha}$ -amylase activity in blood. Activity was significantly elevated by 25% (^***P<0.001) in circulating blood serum of SLOS mice compared with the level in WT serum. Values are mean ± s.e.m. of five animals from each group.