Fig. 7. Dense core granule formation in endocrine tissues of Sc5d^-/- mice. At E18.5, DCGs are plentiful in the anterior pituitary (A), adrenal medulla (C) and endocrine pancreas (E) of control mice, whereas mice homozygous for the Sc5d mutation show absent or severely reduced presence of electron-dense granules (arrows) in equivalent regions of tissues (B,D,F). n, nucleus. Bars, 1 µm (A-B); 2 µm (C-D); 500 nm (E-F).